The biosensor records and creates images of tissues and organs


A patent pending novel Purdue University biosensor that can be 3D printed with automated printing technology may soon allow surgeons to locate critical areas of organs and tissues during surgery.

A fully printable biosensor composed of soft bio-ink interfaces with a pig’s heart. Research on the biosensor, developed by researchers at Purdue University and Los Alamos National Laboratory, has been published in Nature Communications. Image credit: Bongjoong Kim.

Chi Hwan Lee invented the biosensor, which allows simultaneous recording and imaging of organs and tissues during surgery. Lee is Leslie A. Geddes Assistant Professor of Biomedical Engineering at the Weldon School of Biomedical Engineering and Assistant Professor of Mechanical Engineering. He also holds a courtesy position in materials engineering.

Simultaneous recording and imaging could be useful during heart surgery to locate critical regions and guide surgeries such as a procedure to restore normal heart rhythms.

Chi Hwan Lee, Leslie A. Geddes Assistant Professor, Biomedical Engineering, Weldon School of Biomedical Engineering

Standard techniques for simultaneously recording and imaging organs and tissues are known to be difficult because other types of sensors used for recording purposes generally interfere with the imaging process.

To this end, we have developed an ultra-soft, thin and expandable biosensor that is able to interface seamlessly with the curvilinear surface of organs; for example, the heart, even under great mechanical deformations, for example cardiac cycles. This unique feature allows simultaneous recording and imaging, allowing us to accurately indicate the origin of disease conditions: in this example, real-time observations of the spread of myocardial infarction in 3d.

Chi Hwan Lee, Leslie A. Geddes Assistant Professor, Biomedical Engineering, Weldon School of Biomedical Engineering

Biosensors accommodate a range of organ shapes and sizes using soft bio-inks when rapidly prototyping a custom design. Softer than tissue, bio-inks stretch without causing degradation to the sensors and have a constant natural adhesion to the wet surface of organs without the need for additional adhesives. The Kwan-Soo Lee research team at Los Alamos National Laboratory is in charge of the formulation and synthesis of the bio-ink.

Many prototypes of biosensors of different sizes, shapes and combinations have been created. Craig Goergen, Leslie A. Geddes associate professor of biomedical engineering at the Weldon School of Biomedical Engineering at Purdue University, and his research team evaluated the prototypes in pigs and mice in vivo.

Professor Goergen and his team were able to identify the exact location of myocardial infarctions over time using the prototype biosensors. In addition to these tests, they also assessed the biocompatibility and anti-bio-fouling properties of biosensors, as well as the effects of biosensors on cardiac function. They showed no significant side effects.

Chi Hwan Lee, Leslie A. Geddes Assistant Professor, Biomedical Engineering, Weldon School of Biomedical Engineering

The research on biosensors has been published in the peer-reviewed journal, Nature Communication.

Journal reference:

Kim, B., et al. (2021) Rapid and personalized prototyping of a flexible poroelastic biosensor for simultaneous epicardial recording and imaging. Nature Communication. doi.org/10.1038/s41467-021-23959-3.

Source: https://www.purdue.edu/


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